Isolation,purification and activity of active componentsfrom Rubus corchorifolius leaves and their inhibitioneffects on movement of isolated rabbit intestinal
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Graphical Abstract
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Abstract
In order to ensure the anti-diarrhea components from Rubus corchorifolius leaves,the active componentsfrom R. corchorifolius leaves were isolated and purified using solvent extraction,column chromatography and middlepressure column chromatography,and their anti-diarrhea activities were determined through the movement of isolatedintestinal of rabbit,meanwhile,the structure of active monomer was identified. The results showed that the componentwhich had anti-diarrhea activity on isolated intestinal was P-hydroxy ethyl cinnamate in R. corchorifolius leaves,whenthe concentration was 20 mg/mL,the change rate of tension increment of isolated intestinal reached 70.0%,and itsinhibition effect was better than that of atropine.
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