Application of Aptamer Biosensor Technology inthe Quantitative Detection of Salmonella

Salmonella is an important zoonotic pathogen, which leads to the highest number of food poisoning cases in the world. At present, biosensors based on antigen/antibody, aptamer, cell and other sensing elements have been widely used in the quantitative detection of Salmonella. Among them, aptamers are short nucleotide sequences which have the advantages of strong specificity, high affinity, fast synthesis, good reproducibility and convenient modification. Those advantages make it possible to be a potential for use as a recognition probe to replace antibody in the diagnostic field. Therefore, aptasensors have unique advantages in the quantitative detection of Salmonella. This paper focuses on the application of aptasensors in Salmonella detection. First, salmonella and their common detection methods were summarized. Second, Salmonella aptamer screening by SELEX was introduced. Then the application of aptasensors based on colorimetry, fluorescence, surface-enhanced Raman scattering (SERS) and electrochemistry to detect salmonella were reviewed in detail. Finally, the development in the application of aptasensors for the quantitative detection of salmonella were previewed.