Abstract: Chlorogenic acid is an important polyphenolic compound in plants, which plays an important physiological role in plant growth and development, disease and pest resistance, cold resistance and other stresses. It has a variety of pharmacological functions, including anti-inflammatory, antibacterial, antiviral, anticancer, anti-ultraviolet light and radiation, immunoregulation, hypolipidemic, hypoglycemic, etc. Chlorogenic acid has great potential especially in functional foods, nutritional supplements, raw food materials, chemical industry and drug development. Tomato, eggplant, pepper, potato and tobacco are important cash crops in the world. They are all important types of Solanaceae plants, and also important sources of chlorogenic acid. The content of chlorogenic acid in fruits or vegetative organs of Solanaceae crops varies greatly, and their chlorogenic acid anabolism is a complex biological process determined by genetic and environmental factors. Therefore, the research on biosynthesis and molecular mechanisms of regulation of chlorogenic acid in Solanaceae crops has important theoretical significance and application value for crop genetic improvement. The article outlines the content of chlorogenic acid in the above five Solanaceae crops, the biosynthetic pathways and transcriptional regulation molecular mechanisms of chlorogenic acid, and the effects of genotype differences, environmental factors, cultivation measures on chlorogenic acid content in Solanaceae crops, which is expected to provide theoretical bases for the development and utilization of chlorogenic acid in Solanaceae crops, the creation of germplasm resources with high chlorogenic acid and the breeding of new varieties of Solanaceae crops.