Abstract: 【Objective】The experiment is to breed a new variety of fresh-eating sweet potato with high quality and disease resistance.【Method】As the female parent, Guangshu 87, a variety with cross-incompatibility group of 88-70, broad adaptation, disease resistance and high yield, and as the male parent, Guangshu 79, a variety with cross incompatibility group of D, good edible quality and high carotene, were selected for directional hybridization, then seeding and selecting the lines, which were subjected to a reselection test, a comparison test, and a regional test in Guangdong to evaluate the adaptability and the disease resistance identification.【Result】The new sweet potato variety“Guangshu 72”was bred. In provincial multi-location adaptability test, there was an average yield of fresh root and dry root of 2 350.0 kg and 672.9 kg per 667 m2, which was 21.6% and 24.4% higher than that of the control variety Guangshu 111, respectively, both reaching an extremely significant level. The dry matter rate and starch content of the root were 28.7% and 19.7%, respectively. The carotene content of fresh root was 81 mg/kg. The steamed root was powdery and sweet, with good taste and a taste value of 80-85 scores. The resistance to bacterial wilt of field test was identified as medium resistance, and that of indoor test was identified as resistance.【Conclusion】The special fresh-eating sweet potato variety Guangshu 72 is characterized with high quality, high yield, wide adaptability, outstanding commodity value and good palatability, which is conducive to promoting the production of sweet potato and improving the social and economic benefits of sweet potato cultivation. In 2016, it passed the variety approval of Guangdong Province.