Abstract: In order to select the varieties of flue-cured tobacco suitable for planting in Qianxi County, and promote the sustainable development of tobacco production, the botanical, agronomic, economic and qualitative characters of 10 varieties bred in recent years, such as Guiyan 201, were measured and Grey Relational Analysis was carried out for comprehensive analysis. The results showed that the plant height, pitch, stem circumference and apical leaf of Guiyan 201, Guiyan 202, PVH1452, Bina No. 1 were in good condition. The economic characters of Guiyan 201 were the best, reaching the output value of 55 169.34 yuan / hm2, followed by Guiyan 202, Bina No. 1 and Guiyan No. 4, which were significantly superior to the control variety K326. The chemical composition and coordination of Jinhai No.1, Guiyan 202 and Guiyan 201 were slightly better than that of the control; the sensory qualities of Yunyan 110, Yunyan 87 and Jinhai No.1 were superior to that of the control. The comprehensive performance of Guiyan 201 (0.8835), KRK26 (0.8835) and Guiyan 202 (0.8524) was obviously better than that of the control varieties - K326 (0.7891) and Yunyan 87 (0.7621), and the comprehensive performance of Guiyan No. 4 (0.8068) and Bina No. 1 (0.8032) was slightly better than that of the control. It suggested that Guiyan 201, KRK26 and Guiyan 202 were suitable for demonstration and promotion in Qianxi County while Guiyan No. 4 and Bina No. 1 should be further demonstrated and verified on a larger scale.