Abstract: As the only provincial-level scientific research institution specializing in rice research, the Rice Research Institute (RRI) of Guangdong Academy of Agricultural Sciences has made great achievements in the researched of rice breeding, such as breeding for dwarf rice, high-quality conventional rice breeding, hybrid rice breeding and super rice breeding. It has cultivated numerous rice varieties approved through all levels of inspection, including a batch of important parent materials widely applied by the seed industry peers, and a number of outstanding indica rice varieties widely used in southern China. It has made major contributions to the development of the rice seed industry in southern rice regions and even the whole country and the national food security, and has established the status of"China Indica Rice, Guangdong Seed Core". Since 2011, with the implementation of the Opinions of The State Council on Accelerating the Development of Modern Crop Seed Industry (state issue〔2011〕No. 8) and other documents, scientific research institutes and universities have gradually been restricted in commercial breeding researches, such as regional test indicators for hybrid rice varieties. In a bid to adapt to the new situation, the RRI strengthens the cooperation between science and technology and enterprise through the transfer of varieties, entrusted breeding and technical services so as to seek collaboration with seed enterprises which owns strong promotion ability and is close to the market, and these enterprises play their respective advantages to jointly carry out variety transformation and promotion, and good results are achieved. It has fostered and developed a number of seed enterprises, promoted the large-scale application of a batch of varieties in production, and enhanced the scientific and technological innovation of rice and the development of the seed industry. In addition, the main direction of rice breeding and the cooperation between science and enterprise in the future is analyzed.