Abstract: Diapause is a physiological process for most insects to be existent in a seasonal and adverse natural environment, and it has a very important influence on insects爷survival, evolution and propagation, etc. The paper reviewed the reason of diapause, internal and external factors of influence, endocrine mechanisms, diapause related enzymes,proteomics and molecular biology of diapause and research on concerned regulatory pathway, to provide references for researching the relationship among hormones, enzymes and diapause-associated protein and learning the diapause action and molecular mechanism of diapause, from population to individual and from macroscopic to microcosmic.