Abstract: The effects of different seasons and anaerobic treatment on the key pollution indicators in cattle farm sewage were studied. The result showed that different seasons and anaerobic treatment had significant influence on the main pollution factors of wastewater. The contents of polluted ingredient in spring and summer were higher than those in autumn and winter. However, after anaerobic treatment, the key pollution indicators in winter and spring were higher than those in summer and autumn. After anaerobic treatment, the key pollution indicators in sewage including CODcr, NH4+-N,nitrogen and zinc decreased significantly.