Abstract: Chinese giant salamander (Andrias davidianus) is a rarely endangered species and the largest amphibian in the world, and listed as Class II state major protected wildlife species in China. Because the population of wild Chinese giant salamanders has dropped sharply, Chinese giant salamander is artificially farmed in mesocosms for research and conservation. Recently, infectious diseases are implicated in the declines and the economic loss in cultured and wild Chinese giant salamander. Pathogens infecting giant salamander include bacteria, fungi, parasites and viruses, including ranavirus associated with mass mortality in outbreaks of epidemic diseases from 2011. The research progress on these pathogens, their biochemical and biological properties, the susceptibility to antibiotics and pathogenic characteristics are briefly reviewed. This will benefit to the better understanding of pathogenesis and molecular infection mechanism for giant salamander, and will also help to the findings of anti-infective therapy.