Abstract: The performance detection experiments of the metering device was designed and optimized by response surface method (RSM) in this paper. A quadratic regression model describing qualified index as a function of 2 factors was created based on a 5-level quadratic orthogonal rotation combination design, the relationship of the various factors on the response value was analyzed. The optimal experiment conditions were found as follows: rotational speed of 42 r/min and atmospheric pressure of 472 mm H2O. Under the optimal conditions, the qualified index of the experimental test was 94.8712, the model predicted value was 92.7688, which was basically consistent. The experiments showed that the quadratic orthogonal rotation combination design combined with the response surface method was suitable for the optimization and analysis of the metering device performance testing experiments.