Abstract: A new hybrid rice combination “Y Liangyou 7238”has been breed by Zhaoqing Institute of Agricultural Sciences and China Seed Group Co. Ltd.. It is crossed between the male sterile line “Y58S” and the restore line “R7238”. The restore line “7238” was selected from a progeny of crossing between the high-quality conventional rice cultivar “Wushanyouzhan”and the anti-blast restorer line “R238”. Then “R7238” was hybrided with a PTGMS line “Y58S” for a new bilinear hybrid rice combination “Y Liangyou 7238”. The yield of this combination highly significantly increased in comparison with control. The rice quality reached the top (third) level of the Guangdong rice quality standards. This combination showed medium resistance to rice blast and medium susceptibility to rice bacterial leaf blight. “Y Liangyou 7238”, which passed the crop variety validation in Guangdong in June 2012, provided a solution to the technical gap of the combination of high yield, disease resistance, and good quality. Here, we describe the breeding process, the major characters,and the key seed-production technology of “Y Liangyou 7238”.