Abstract: Loose leaf lettuce can grow all the year round. In order to improve product quality, ensure food security, the paper introduced the production environment conditions, the variety selection, culturing vegetable seedling, fertilization and water managements,and summarized comprehensive preventive health measures of agriculture, organism, physics,chemistry of the main diseases and pests,harvest, and established file with pollution-free loose leaf lettuce production in Huizhou. It was a guidance of pollution-free loose leaf lettuce production in Huizhou.