Abstract: Grape is one of the main types of fruit trees in China, which is rich in nutritional value and loved by consumers. With the application of rain-shelter cultivation technology and dormancy release technology, grape planting has been gradually expanded from the traditional producing northern areas to the southern areas. Grapes protected cultivation in Guangdong effectively overcome the shortcomings of climatic conditions, and have the characteristics of quick effects and high returns. This model has gradually become a new bright spot in agricultural development of Guangdong. In order to understand the situation of grape protected cultivation in Guangdong, a comprehensive investigation and analysis was made from the current situation of grape protected cultivation at home and abroad, and the general situation, models, types, varieties and cultivation techniques of grape protected cultivation in Guangdong. Besides, the existing problems and corresponding countermeasures were analyzed. The results showed that the area and yield of grape protected cultivation in Guangdong continued to increase, and remarkable progress was achieved in the cultivation mode and standardized cultivation techniques. However, there were still many problems in grape protected cultivation in Guangdong, such as single variety structure, low standardization and scale of grape protected cultivation, weak market competitiveness and unreasonable cultivation facilities. In view of the above problems, the corresponding countermeasures were put forward. The key points were to further strengthen the breeding of new grape varieties, improve the standardization and intelligence level of protected cultivation, and develop suitable anti-typhoon and high-temperature shelter facilities for grape cultivation in Guangdong region, pay attention to brand development, achieve the integration of three industries, reduce the production costs, improve economic benefits, give full play to the regional advantages, promote the transformation of grape production from "quantitative benefit" to "quality benefit", and realize the sustainable development of Guangdong grape industry.