Abstract: 【Objective】By analyzing the impacts of Sino-U.S. trade frictions on Guangdong Province’s aquatic product trade to the United States, relevant countermeasures and suggestions were put forward to mitigate the negative impacts of Sino-U.S. trade frictions and promote the transformation and upgrading of aquatic product enterprises in Guangdong. 【Method】Combined with the statistical data and semi-structured field survey, this paper used TC index method to analyze the current situation of Guangdong Province’s aquatic product trade to the United States, and discussed the impact on the market of Guangdong Province’s aquatic product to the United States under the background of Sino-U. S. trade frictions from macro to micro, and put forward countermeasures and suggestions from the perspectives of enterprises, industries and governments.【Result】After the Sino-U.S. trade frictions in 2018, export trade of aquatic products of Guangdong Province faced greater uncertainty. From a macro perspective, it led to the decline of competitiveness of aquatic products, the trade surplus turned into trade deficit, the export of aquatic products to the United States was blocked, the proportion of domestic sales increased, and some aquatic products exported to the United States turned to be sold to the ASEAN and Australian markets; from a micro perspective, it had a negative impact on the upstream, midstream and downstream links of aquatic products, for example, the non-US and domestic markets was widened, the processing volume was reduced, and the breeding plan was not clear.【Conclusion】Guangdong aquatic products enterprises should take into account the domestic and foreign markets to stimulate consumption potential, lead the farmers to change the breeding mode to improve their anti risk ability, strengthen scientific research and enhance the core competitiveness fundamentally. Trade associations should play a leading role in jointly preventing risks. It is also suggested that the government should introduce relevant supporting policies and cooperate with enterprises to deal with Sino-U.S. trade frictions in a more leisurely manner.