Abstract: 【Objective】The technology of chemical fertilizer application reduction is an important way to avoid environmental pollution caused by excessive fertilization and promote the sustainable development of agriculture. This study was conducted to explore the replacement of chemical fertilizer with organic fertilizer, and provide scientific basis for the application of commercial organic fertilizers in winter potato by replacing chemical fertilizers.【Method】With Favorita as experimental material, the effects of three commercial organic fertilizers and chemical fertilizer treatments on yield, economic benefit, apparent fertilizer use efficiency and quality of winter potato in Guangdong Province were studied.【Result】There was no significant difference between the quality of potato tubers treated with organic fertilizer and chemical fertilizer. Among the three organic fertilizer treatments, the commercial organic fertilizer 2 had higher total yield, marketable tuber yield and total value than those of the other two commercial organic fertilizer treatments while the cost was lower than that of the other two. The apparent fertilizer use efficiency of commercial organic fertilizer 2 was 10.17%, which was 1.96% and 3.52% higher than that of commercial organic fertilizer 1 and commercial organic fertilizer 3, respectively. The organic manure equivalenceof commercial organic fertilizer 2 treatment was 66.02%. Overall, commercial organic fertilizer 2 was a better choice with a good price in the process of replacing chemical fertilizer with organic fertilizer in winter potato. 【Conclusion】The organic fertilizer could partly replace chemical fertilizer in winter potato cultivation, and achieve reduction of fertilizer application.