Abstract: 【Objective】 Based on the long-term historical data of land use, the change and transformation characteristics of land use structure in Guangdong Province under the background of sustainable development of industrialization and urbanization were analyzed. 【Method】 With the help of landscape pattern index and ArcGIS analysis method, this paper described land use change from types and quantities by using structural diversity and concentration degree analysis to make up for the deficiency of ignoring the structural commonness of stages at uniform time intervals, and to explore the quantitative structure, allocation, time transfer and characteristics of land use in Guangdong Province in the past 35 years of reform and opening-up, and the main socio-economic driving forces. 【Result】In recent 35 years, the main land use combination in Guangdong Province was “forest land + paddy field”, the stage change of land type structure had obvious time nodes (1990, 1995, 2000). According to the time sequence of node division, the characteristics of land type transfer and the comprehensive dynamic degree of grid space in each stage were analyzed, and the driving factors showed that the number of permanent residents and the regional gross domestic product (GDP) were the core driving forces for land dynamic monitoring. The coupling relationship between human activities and land use under the background of urbanrural transformation could be studied intensive, and the "dilemma" between social development and land use could be solved. 【Conclusion】 The study of dynamic monitoring of regional land use needs to be understood from the perspective of stages, diversity and complexity. This paper reveals the characteristics of quantitative structure and allocation evolution of long-term land use since the reform and opening-up in Guangdong Province in the process of urbanization, which has a certain reference value for further exploration of human-land coupling relationship.