Abstract: Omics includes genomics, transcriptomics, protemics, metabolomics, ionomics etc. With the continuous development of sequencing technology and sequencing methods, multi-omics association analysis has become a common technical method to study the crop response to stress. On this basis, the research on genes controlling important agronomic traits were conducted. The research progresses of correlation analysis of different omics combinations such as transcriptomics and proteomics, transcriptomics and metabolomics, proteomics and metabolomics, transcriptomics, proteomics and metabolomics in crop response to adversity stress (abiotic or biotic stress), gene function and assistant breeding were summarized. It also looks forward to using the data of comprehensive analysis to verify the selected core data and its application in breeding. The research method of multi-omics combinations can reveal the molecular mechanism of crop response to stress and provide new ideas for the cultivation of stress resistant varieties in the future.