Abstract: 【Objective】The high-quality development of agriculture is the direction of China’s agricultural development. As a large agricultural province, Guangxi adheres to the high-quality development of agriculture, which is conducive to improving the level of agricultural modernization in Guangxi. Based on the analysis of industrial structure and aggregation in Guangxi, and this paper explores the high-quality development path of Guangxi agriculture, and provides theoretical references for the high-quality development of Guangxi agriculture.【Method】 The 14 cities in Guangxi were divided into two grades, and the fixed effect model was used to study the upgrading rate of industrial structure, the optimization rate of industrial structure, the degree of regional specialization and the factors affecting the upgrading of industrial structure in Guangxi during 2013—2017. 【Result】 Beihai City, Fangchenggang City and Qinzhou City was developed relying on Beibu Gulf, the industrial structure upgrading rates of the three cities are more than 50%, and the industrial structure has the highest growth rate of 363%. The average values of optimization rate of the primary industry structure and the dominant areas are above 2%. Through the fixed effect model processing of independent variables by Eviews, it is found that there is significant heterogeneity in the industrial upgrading trend in various regions of different grades. The optimization and aggregation of industrial structure and the improvement of labor quality are the key points to the high-quality development of agriculture. The investment in agricultural mechanization and infrastructure has a significant impact on the excellent and inferior areas, which is the basis for the high quality development of agriculture.【Conclusion】 It is suggested to reduce the differences in regional industrial structure upgrading by coordinating the comprehensive development of different areas, to accelerate the cultivation of productive technical service subjects and provide large-scale high-quality agricultural technology services, to improve the optimization and concentration of industrial structure and the quality of labor force, to facilitate the application of the combination of agronomy and agricultural machinery, and strengthen infrastructure construction for the promotion of the highquality development of agriculture.