Abstract: 【Objective】The objective of the study is to screen suitable soil amendments for sandy soil in Nanxiong tobacco-growing areas.【Method】The effects of different soil amendments on tobacco yield, quality and soil physical and chemical properties were studied through field experiment.【Result】The results showed that the soil amelioration effect of bio-carbon was better than that of mineral conditioner. The yield and output value of tobacco leaves treated with biocarbon were significantly higher than those of control group, with an increase of 20.00% and 54.02% respectively. And the proportion and average price of superior tobacco were 84.18% and 27.54% higher than those of control group. The nicotine content, potassium content, total nitrogen content, chlorine content and protein content of flue-cured tobacco treated with bio-carbon were within the appropriate range, the sugar-alkali ratio was between 8 and 12, and the chemical composition of flue-cured tobacco was more coordinated. Bio-carbon and mineral conditioners could improve soil pH, physical and chemical properties and effective nutrient contents in soil. Bio-carbon could improve soil enzyme activity in tobacco-growing soils, and its exchangeable calcium and exchangeable magnesium contents were 30.75% and 19.33% higher than the control group, respectively.【Conclusion】 Bio-carbon treatment (1 500kg/hm2) had obvious effects on improving the yield and quality of tobacco leaves and the physical and chemical properties of soils in sandy soil of Nanxiong tobacco-growing areas.