Abstract: 【Objective】The study was conduct to explore the effects of chlorantraniliprole on the toxic activity, walking ability, climbing ability and adhesion ability of small and medium-sized Solenopsis invicta Buren. 【Method】 The toxic activity of chlorantraniliprole against S. invicta Buren was assayed with aqueous solution tubes method. 【Result】The results showed that the corrected mortality of the small-sized S. invicta Buren was 96.55% after treatment with 8 mg/L of chlorantraniliprole for 60 h. The corrected mortality of the medium-sized S. invicta Buren was 100.00% after treatment with 16 mg/L of chlorantraniliprole for 60 h. After treatment with 8 mg/L chlorantraniliprole for 36 h, the walking rate, climbing rate and adhesion rate of the small-sized Solenopsis invicta Buren were 15.00%, 15.00% and 11.67%, respectively. After treatment with 16 mg/L chlorantraniliprole for 36 h, the walking rate, climbing rate and adhesion rate of the medium-sized Solenopsis invicta Buren were 15.00%, 13.33% and 11.67%, respectively. 【Conclusion】 Chlorantraniliprole shows good toxic activity and behavior effects on small and medium-sized S. invicta Buren, and has a good application prospect in the prevention and control of S. invicta Buren.