Abstract: 【Objective】This study aimed at determining the appropriate amount of commercial organic fertilizer for winter potato production in order to provide technical support for the rational application of commercial organic fertilizers in the actual production process of winter potato in Guangdong Province.【Methods】With CK(no fertilizer application) and CF(only chemical fertilizer without commercial fertilizer application) as the control treatments, five different amounts of commercial organic fertilizers (Treatment 1-5∶3000 to 15 000 kg/hm2 ) were designed, and the tuber yield, economic benefits, and tuber quality parameters were measured at harvest time.【Results】The tuber yields of winter potato increased with the increment of the amount of commercial organic fertilizer, and the yield of Treatment 5(15 000kg/hm2) was up to 40 871 kg/hm2(maximum yield). The dry matter rate of each treatment ranged from 18.63% to 20.05%. The comprehensive economic benefits of Treatment 3 (9 000 kg/hm2) was up to 75 318.75 yuan/hm2. By using quadratic equation to simulate the regression relationship between the economic benefits and the application amount of commercial organic fertilizer, it was found that when the application amount of commercial organic fertilizer was 9 077.23 kg/hm2, the economic benefit was maximum, reaching 74 872.31 yuan/hm2, and the equation simulation was consistent with the actual production situation in the field experiment. In terms of the tuber quality, There was no significant difference with dry matter rate, Vc content of fresh potatos and starch content of tubers with different treatments. The increased yield per 100 kg of commercial organic fertilizer was also the highest in Treatment 3, reaching 47.56 kg.【Conclusion】Under the test conditions, the optimal fertilization pattern with“1 base manure+0 top dressing”for winter-cropping potatoes is 1 500 kg/hm2 of potato special fertilizer plus 9 000 kg/hm2 of commercial organic fertilizer in winter potato production.