Abstract: According to the present situation of Jiangxi tobacco producing areas of organic and inorganic fertilizers and many kinds of research is not thorough，choosing 7 kinds of common organic and inorganic fertilizer， fertilizer through contrast test，analysis of effects of different kinds of organic and inorganic fertilizer on tobacco growth，yield and quality，in order to select suitable for high quality tobacco use of organic and inorganic fertilizer， and provide scientific basis for the selection of high quality fertilizer. The results showed that the net photosynthetic rate of the golden leaf organic-inorganic fertilizer treatment was 17.4 μmol/m2·s. The tobacco plant showed early fast hair，the output value per unit area was the best，each 667 m2 reached 3 967.9 yuan，the comprehensive score of sensory quality was 76.75，and the comprehensive effect was the best. The golden age，Saint Nong and Best treated early and fast and economical. Well，the output value of each 667 m2 was 3 451.6-3 624.3 yuan，but the sensory quality was slightly poor and the comprehensive score was 74.25-75.00. The economic characters of Tian De，cloud leaf and Qi He are generally 2 863.3-3 381.3 yuan per 667 m2，but the sensory quality was good，and the comprehensive score was 77.00-77.75，indicating that the organic and inorganic fertilizer of Tian De，Yun leaf and Qi He were larger. Potential application should be further improved according to the particle size and nutrient characteristics of fertilizer. The chlorine content of tobacco leaves in Jiangxi is low. Under this test condition，the amount of chlorine ion of organic and inorganic fertilizer applied for every 667 m2 is 1.8-2.3 kg，and the content of chlorine in tobacco leaves is more suitable.