Abstract: A field experiment was conducted to study the effects of different proportions of cake fertilizer and organic manure on the growth of flue-cured tobacco cv. yunyan87 and the improvement of soil properties. The results indicated that the pure cake fertilizer may have a positive effect on the growth of tobacco plants and soil enzyme activity. Potential benefits of land application of cake fertilizer would make the tobacco plant grow faster in which growth periods were 1-3 days in advance and increase its maximum dry matter accumulation. The content of plastid pigment，which can significantly increase the aroma of tobacco leaves，gradually increased up to 25.82% with the increase of the amount of cake fertilizer used. The combination of cake fertilizer（ 10% organic nitrogen） and organic fertilizer（ 10% organic nitrogen） can improve the coordination of chemical composition of tobacco leaves，reduce the content of nicotine and improve the intrinsic quality of tobacco leaves. The results indicated that the application of cake fertilizer and organic manure in Jiangxi would contribute most significantly improve the quality of tobacco leaves and increase the net economic returns of the cured tobacco.