Abstract: In order to systematically understand the inflammatory system of goose，the total RNA was extracted from the spleen of Magang goose by Trizol method. The caspase-1 gene of goose was cloned by RT-PCR and the bioinformatics analysis was carried out. Sequencing results showed that the complete ORF region of the go-Caspase-1 gene was 813 bp，encoding 270 amino acids（ GenBank ID NO：MG463109）. Homology analysis showed that the sequence of go-Caspase-1 was homologous to duck and chicken，and its differences with other species were relatively large. Protein functional domain analysis showed that the number and distribution of Caspase-1 protein domains were similar in different species. The three-dimensional structure of protein showed that the structure of go-Caspase-1 was similar to that of chicken and human Caspase-1.