Abstract: In order to screen out soil improvement agent suitable for karst area soil，who can not only improve the soil，but also reduce the risk of soil nutrient loss，the adsorption characteristics of different materials to nutrient in solution and the effect of indoor simulation on soil nutrient loss in karst soil were studied. The primary results were as follows：the total surface loss of nitrate nitrogen，ammonium nitrogen，available phosphorus and available potassium were 625.42 mg，614.51 mg，558.47 mg，411.24 mg，391.80 mg，respectively. The results showed that all the experimental treatments could reduce the total amount of nutrient surface runoff ，increase the zeolite ，and the amount of fly ash was expected to further reduce the loss. All the treatments could decrease the total nutrient loss compared to CK treatment，and utilization of more zeolite and coal ash was promising for declining nutrient loss. The adsorptive characteristics of nutrients was directly related to nutrient variety and adsorptive material. The results showed that the combination of zeolite and fly ash showed a better effect and was expected to be a material combination used to reduce soil nutrient loss in karst region.